A new application called 'minirosetta' has been released. This application is a complete restructuring of the current rosetta applicaton and was designed to facilitate future development and science. Our goal is to gradually transition to this application as it matures. Graphics are not yet available but are currently under development. Please post any issues/bugs in this thread. We'll be issuing tasks in relatively small batches soon
wäre schön wenn das einer übersetzen könnteThese are exciting times!
first, please bear with us! the all new beautiful completely object oriented C++ rewrite version of Rosetta is now running on your computers. old timers will recall that in the early days of the project, it took sometime before all the kinks were worked out, and that the graphics took some time to get to the very nice state we have all become used to. the new version of rosetta is extremely powerful, but as it is very new, there are still some rare problems surfacing, and some of the bells and whistles, such as the screensaver, are not yet in place. similar issues have been slowing us down a bit with our in house research and computing projects. rest assured however, that these problems will be solved quite soon, and the new version is so much more powerful that this inconvenience will be made up for many fold.
second, the game continue to progress, and I think is getting more and more fun to play. still some things to work out, so not quite ready to go public, but I encourage any of you who are interested to give it a try (see thread below).
third, as I alluded to in my last post, we have two very exciting papers describing a major breakthrough--the computer based design of new enzymes catalyzing novel chemical reactions-- that will be appearing soon, for a preview you can look at the current online issue of Nature.
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in dem magazin science wurde was von rosetta veröffentlichtThe most recent of the many scientific papers that have come out of all of your efforts at rosetta@home is in today's issue of Science magazine:
http://www.sciencemag.org/cgi/content/a ... /5868/1387
This paper describes the computational design of new catalysts for chemical reactions. Among the many applications are removal of toxic compounds in the environment (bioremediation), making much easier difficult steps in the synthesis of drug molecules, and the generation of new biofuels.
Thanks again for all of your help!
neu in der version sind die grafiken *in betaphase oder so*This version now includes graphics, but only for windows machines. A mac version of the graphics also exists but in version 1.09 is unfortunately nonfunctional. The new graphics are still a work in progress, and as such are going to be different from what everyone is used to.
We have two goals for this release. The first is to verify how some of rosetta's key protocols have survived the move into minirosetta, and the second is to test new protocols that our switch to minirosetta has made possible. Both sets of protocols will be tested on targets that we consider to be scientifically useful.
For now there will only be a gradual increase in work units running minirosetta, in case we missed any significant bugs during our tests on ralph.
wäre nett wenn das einer übersetzen könnteRosetta version 5.95
This version introduces a new "resampling" method for diversified sampling of beta topologies. It expands the range of conformation space that Rosetta can search by learning promising regions of search space from previous search results
Diese Version führt eine neue "Resampling"-Mehtode zum abwechslungsreich gestalteten erzeugen von Beta Topologien ein. Sie erweitert die Bandbreite räumlicher Konformationen, die Rosetta, durch erlernen vielversprechender Regionen des zu prüfenden Raumes aus früheren Resultaten, erforschen kann
Rosetta 5.96 includes a new procedure for modeling large RNAs where experimental information is available. Basically, constraints that bring together parts of the chain that are further apart in sequence are introduced at later stages of the search.
