Rosetta-News

[cappy]

danke für die übersetzung ,

und was aus journal

Reporter John Bohannon is writing an article for WIRED on rosetta in CASP8 and would like to interview rosetta@home participants who contributed to CASP8 structure predictions about their experiences computing this summer. He can be contacted through

http://boinc.bakerlab.org/rosetta/forum ... true#55703

vllt hat ja da wär intresse sich zu melden

[cappy]

mal wieder eine kleine news

viel spa0 beim knuspern

We are currently participating to the first competition for modeling the structure of an important biological receptor. This protein is much larger than all the targets submitted so far and the calculation should last around 3 hours per model on a normal machine. The jobs start with 'AA2A.' If you have a short run time preference and you notice these jobs running past it, please do not abort them.

[cappy]

und wieder was aus dem journal

We are currently testing our new methods for modeling membrane proteins and for modeling drug binding to proteins in a CASP like prediction challenge. The challenge is described at:

http://jcimpt.scripps.edu/GPCRDock/default.aspx


This is an interesting and important challenge because this class of proteins, called G-protien coupled receptors, are the targets of a large fraction of current drugs. This particular case is hard, because we first have to predict the structure of the protein, and then dock the drug on to the model. Needless to say, this is a huge computational challenge and couldn't be done without all of your contributions!

hier ne google übersetzung

Wir erproben derzeit unsere neue Methoden zur Modellierung von Membranproteinen und zur Modellierung von Drogen-Bindung an Proteine in einem CASP wie Vorhersage Herausforderung. Die Herausforderung besteht darin beschrieben unter:

http://jcimpt.scripps.edu/GPCRDock/default.aspx


Dies ist eine interessante und wichtige Herausforderung, weil dieser Klasse von Proteinen, genannt G-protien gekoppelte Rezeptoren, sind die Ziele der ein großer Teil der aktuellen Drogen. Diesem besonderen Fall ist schwer, weil wir erst einmal zur Vorhersage der Struktur des Proteins, und dann das Medikament Dock auf das Modell. Unnötig zu sagen, das ist eine große Herausforderung und Computational konnte nicht gemacht werden, ohne alle Ihre Beiträge!

[DersaureFritz]

Die Übersetzung liest sich ja lustig!

[cappy]

ja :X na mein englisch ist leider zu schlecht um das selber zu übersetzen wenn einer eine bessere hier postet werd ich die oben austauschen

[DO3PSN]

Jetzt wird mir einiges klar, wir helfen also bei der Optimierung von Drogen-Bindungen

Gruß

Philipp

[X1900AIW]

"Drug" wird begrifflich für Rauschmittel wie Arznei-/Heilmittel verwendet.

[Apfel]

Rosetta down ??? Kann weder Server erreichen noch m eine fertigen pakete uploaden...

bei anderen das selbe Problem ?

[cappy]

ja war down aber wieder da

[DersaureFritz]

Ist eigentlich ziemlich selten,das Rosetta down ist.
Jetzt lüppt es wieder!

[cappy]

mal wieder was aus dem journal

We are entering an exciting new phase with rosetta@home!

We now know that our casp8 team which used rosetta@home plus some human intuition did very much better than our automated server robetta on the casp8 targets (the full results from all groups will be presented at the casp meeting in Italy at the beginning of december). our goal between now and the casp meeting is to develop a completely automated protocol that does as well as our casp8 team. towards this end, we need to do extensive benchmarking of the new methods that were developed by students and postocs in our group working on casp8 this summer. these benchmarks must be on non casp8 targets, so that after we have found the best combination of methodology we can see how well it would have worked during casp8 without risking building in the answer by "memorizing" the casp8 structures. we tried many different approaches this summer, and testing all the different methods on a large comprehensive set of protein structures would normally be impossible, but with rosetta@home and all of you we can get rigorous statistics on the different methods and rigorously determine which metho is best.

Please read researcher Mike Tyka's posts in his thread:

http://boinc.bakerlab.org/rosetta/forum ... hp?id=4388

Mike has set up a fantatsic benchmarking system that will let us determine the best methods to use for protein structure prediction. I'm very excited to start using this myself in the next couple of days!

[Michael H.W. Weber]

Kurze Zusammenfassung: Das CASP8-Team hat also bessere Ergebnisse geliefert, als der automatisierte Robetta-Server und jetzt will man probieren, das Vorgehen des CASP8-Teams zu automatisieren.

Michael.