Rosetta@home tries to predict protein structures and protein binding. The goal of the project is to develop methods that can safely predict protein structures from amino acid sequences. These methods can help combat diseases such as cancer, HIV or malaria. Rosetta was developed by the University of Washington and is considered the best program for predicting the protein folding, since it has achieved always very good results in the CASP-competition.
Unlike the Human Proteome Folding Project that uses the Rosetta software, Rosetta@home attempts to improve the Rosetta software itself. That is why the project belongs to the category basic research.
A special feature of the project is, that you can set the calculation time of the work unit (wu) in your account. This has no scientific, but an organizational background: with longer WUs the server of the project and the bandwidth of the user are spared. However, each WU does at least one complete convolution simulation before it is terminated. For a randomly complex protein, a WU can run for 6 hours or even longer, even if it has a much shorter runtime. Before changing the so-called "target CPU run time", you should have all open WUs processed and only after the change load new tasks. 
Detailed Audio-Description of the project (German): BOINCcast
There is a separate project that tests program versions before they are acquired by Rosetta. It is called: Ralph@home.
In addition to grid computing, the researchers of this project also try to use the concept of Distributed Thinking. To this end, they have developed the foldit game, along with other members of the Computer Science and Engineering and Biochemistry departments of the University of Washington, where the player folds proteins himself.
|Goal||Predicting protein structures|
|This project is being conducted in Washington, USA.|
- Background information
- View self-calculated protein structures
- Join in
- Mailing list/Forum
- Very current information about the status and achievements of the project
- e-Library (RKN-Wiki)
- Introduction to the problem addressed by the project
- Disease control through protein structure predictions
|Wo||Übersicht||Top Teams||Top User|
|Projekt Home Page||Top Teams||Top User|
|BOINCstats.com||Übersicht||Top Teams||Top User|
|stats.free-dc.org||Übersicht||Top Teams||Top User|
|MacOS X 64bit|
|Java (OS independent)|
|Funktioniert auch über Proxy|
|Normal ausführbares Programm|
|Als Bildschirmschoner benutzbar|
|Personal Proxy für Work units erhältlich|
|Work units auch per Mail austauschbar|
|Auch offline nutzbar|
- You can set the running time of the work units on the website. There are settings from one hour to one day. The default is 3 hours. If the error rate is low, a longer duration is recommended.
The most recent versions are published here.
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- 09.03.2007: promotional video about Rosetta@home
- 20.08.2006: BOINCcast #14 - rosetta@home und Updates
- 10.05.2006: Open Source Bioinformatics
- 10.05.2006: Voltage sensor conformations in the open and closed states in ROSETTA structural models of K+ channels
- 06.04.2006: Next cancer breakthrough from your home PC?
- 11.01.2006: Protein Detectives
- 25.10.2005: PDB Molecule of the month
- 24.09.2005: Top predictions
- 24.09.2005: Welcome from David Baker
- 21.09.2005: Cracked: the puzzle of protein origami