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RNA World ã??ã?­ã?¸ã?§ã?¯ã????æ??

RNA World ??ã?RNA ?ç ??ã??æ?¨ã?ã??ã?ã??ä½?ã??ã??ã?ã?¹ã?¼ã??ã?¼ã?³ã?³ã??ã?¥ã?¼ã?¿ã?·ã?¹ã??ã? ?ã?ã?? ã??ã?·ã?¹ã??ã? ?ã?ã?¤ã?³ã?¿ã?¼ã?ã??ã???æ?¥ç¶?ã?ã??ã?ã?³ã?³ã??ã?¥ã?¼ã?¿??ã????æ§?ç¯?ã?ã???ã??ã?ã?? ??ç?®ç???ã?RNA å?????ã???å?å®??å??æ?ã?æ§?é? äº????è¨?ã??ã?ã??ã???ã?ã??ã??ç«?æ¸???ã?ã?¤ã?ªã?¤ã?³ã??ã?©ã??ã??ã?£ã?¯ã?¹ã?»ã?½ã??ã??ã?¦ã?§ã?¢ã??ã??ã?¼ã?¹?ã??ã?é«?æ?§è?½ã??é«?ã?¹ã?«ã?¼ã??ã??ã???å??ä½?ã??ã?ã??

RNA World ??ã?ã????ã?ã?¤ã?ªã?¤ã?³ã??ã?©ã??ã??ã?£ã?¯ã?¹?ã?¢ã??ã?­ã?¼ã???ç?°?ã??ã?å??ã???ã??ã?¹ã?¯ã??ã??ã??ã?³ã?³ã??ã?¥ã?¼ã?¿ã??ã?¦ã?§ã??ã?µã?¼ã?ã?ã?ã??ã??å??ã???ã?¹ã?¼ã??ã?¼ã?³ã?³ã??ã?¥ã?¼ã?¿ã?¼???å­?ã??ã??ã?ã??ã?? ã??ã?ã?ã??ã?·ã?¹ã??ã? ??æ???ã?ä¸?ç????ã?ã????ã??ã??ã?¿ã?¤ã???ã??ã?·ã?³?ã??æ???çµ???ã???ã?ç¶?ç¶?ç???ç?ºå±???ã??ã??ã?????ã??ã?ã?? å?·ä½?ç???è¨?ã??ã?RNA World ???æ§?æ???ã???ã??å¤?æ§??ã?ã?? ã?µã??ã??ã?­ã?¸ã?§ã?¯ã??ã?????ã?ã??ã????ã??å?¨??ã?ã? Linuxã?Windowsã??ã?? OSX ?ã?ªã??ã?¬ã?¼ã??ã?£ã?³ã?°ã?·ã?¹ã??ã? ã???ã??ã??ã?ã??ã?³ã?³ã??ã?¥ã?¼ã?¿ã??å?å? ã?ã?ã??ã??ã????ã?ã?? ?ã?ã?ã??ã?ã??ã??ã?³ã?³ã??ã?¥ã?¼ã?¿ã????é???ä¸?é?¨??ã??ã??ã????ã?ã?? ã??ã?©ã?³ã??ã?£ã?¢?æ?¹ã??ã??æ??ã???ã??ã??ã?ã?¼ã??ã?¦ã?§ã?¢?é?»æ°???ã?ã?ã??ã?ä»???ã?é??ã??ã?ã?ã??ã???ã??ã?è??å?³?ã?å??æ?ã??å®?è¡???ã??ã??ã???ã??ã?ã??ã?ã???ã?ã??ã?? ?ã??ã????æ???å¿?ã?ã??ã?ã?ã?RNA World ?é?å?¶å?©?é?å?¶ã?ã??ã?ã?ªã?¼ã??ã?³ã?½ã?¼ã?¹?ã?³ã?¼ã??ã???ã?ã?æ?æ???ä¸?è?¬??ã??ã?å?©ç?¨??ã??ã??ã?å?¬é??ã?ã???ã?ã??

?å?¨ã?RNA world ã?å??ä½?ã?ã??ã?ã????ã?Infernal1ã??å®?å?¨è?ªå??å??ã?ã?é«?ã?¹ã?«ã?¼ã??ã??ã??å??æ?ã?½ã??ã??ã?¦ã?§ã?¢?ã?ã?? ã?? Infernal ?å??ã??ã?Sean Eddys laboratory?é??ç?ºã?ã??ã?ã??ã?­ã?°ã?©ã? ã??ã??ã?±ã?¼ã?¸?ã?ã??ã?³ã?³ã?¼ã??ã?£ã?³ã?° RNA ã??ã?·ã?¹ã??ã??ã??ã?£ã??ã?¯?å?å®?ã?ã??ã?ã??ã????ã?ã?ã?? ã?? RNA World ã?µã??ã??ã?­ã?¸ã?§ã?¯ã??(Inferalã?½ã??ã??ã?¦ã?§ã?¢ã??ã??ã?±ã?¼ã?¸?ã??)?ç?®æ¨??ã??å?¨ç?¥ã??ã???ã?ã??ã????æ??æ©?ä½????ã??ã??ã?æ?¢ç?¥?å?¨ RNAã??ã?¡ã??ã?ªã?¼?ã?¡ã?³ã?ã?¼ã????ç«??ã?ã??ã??æ?¹?å?å®?ã?ã????æ??ã??ä¸?è?¬å?©ç?¨??ã??ã??ã??ã??å?¬é??ã?ã??ã???ã?ã?? ã??ã??æ??å?©ã?ã?ã?ã???ã?Rfam2?ã??ã???ç«?ã?ã??ã?ã?ã?¤ã?ªã?¤ã?³ã??ã?©ã??ã??ã?£ã?¯ã?¹?ã??ã?¼ã?¿ã??ã?¼ã?¹?æ??ã???æ?æ??ã??ä¾??ã?ã??ã??ã??ç?®æ??ã?ã??ã????ã?ã?? ã?ã???ã?Rfam ã?å°??ã?ã?ã?ã???å®?ã?³ã?¹ã??å??æ¸??å?©ã???ã???ã?ã??ã?ã??

ä»??å??æ?£ã?³ã?³ã??ã?¥ã?¼ã??ã?£ã?³ã?°ã?ã?ã??ã??ä»??ã?°ã?ªã??ã??ã?³ã?³ã??ã?¥ã?¼ã??ã?£ã?³ã?°?ã??ã?­ã?¸ã?§ã?¯ã????é???ã??å?¨ã?? RNA World ?é??ç?ºè???ä¸?è?¬å??ã?ã??ã?ã?¦ã?¼ã?¶ã?¤ã?³ã?¿ã??ã?§ã?¼ã?¹?é??ç?ºã??ã??ã??ã?ã?? ?ã???ã?æ??ã??è?ª??ç ??ã?ã?¼ã? ã??æ±?ã?ã??ã??ã?­ã?¸ã?§ã?¯ã????è¡?ã??ã?å?±å?ç ??ä½?å?¶?å?¥??ã??ã?å????ç§??è??ã??ã??ç?¬è?ª?ã??ã?­ã?¸ã?§ã?¯ã??ã??ã?¦ã?§ã??ã?µã?¼ã?ã?»ã?¤ã?³ã?¿ã??ã?§ã?¼ã?¹ã????ã?æ?¹æ³??é¡???ã??ã??æ?¹??æ¡?ã?ã??ã???è?½?ã??ã?ã??ã???ã?ã??ç?¡æ???ã??

?ã? RNAã??ç ??ã?ã???ã??

ç??ç?©??è?????ã?ã??ã?ã??ã??ã??è??ç?½??ã?(DNA ??å?ºé?å??ï¼???æ???ï¼??å?º??)ä¸?æ??ç???å?æ?ã?ã??ã? mRNAï¼?ã?¡ã??ã?»ã?³ã?¸ã?£ã?¼RNAï¼? ?å?¼?ã??ã????é«?å???ã?ã??ä½?ã??å?ºã?ã???ã?ã?? ã?? mRNA ?ã?ã???è??å??æ©?æ§???è­?ã?ã??ã???æ©?æ§?ã? mRNA ?æ???å?ºé?å??ã???å¿?ã?ã??è??ç?½?ï¼?ã?¢ã??ã??é?¸?é?£é??é??å?ä½?ï¼??å¤?æ?ã??ã?ã?? ä¸?è?¬ç???ã?ªã??ã?½ã?¼ã? ?å?¼?ã??ã??ã??è??ç?½?å?æ?æ©?æ§??ã?ã?ã???æ©?è?½??ã??? mRNA è?ª?ã?æ???ã?ã??ã?»ã?»ã?»è¨?ã?æ?ã?ã???ã??? RNAå?????æ?§?åª?è?½ã??æ??ã?ã?ã?ªã??ã?¶ã?¤ã? ï¼?ã?ªã??é?µ?ï¼??ã??ã?ã????ã?ã?? ã?ã?ã???è¿????ã??ã?RNA?ã?ã?å??????ã?? tRNAï¼?ã??ã?©ã?³ã?¹ã??ã?¡ã?¼RNAï¼??ã??ã????ã?»é?????ã??ä½?ç?¨ã?ã???ã????ã?è??ç?½??æ§?æ?ã?ã??ã??é?µ??ã??ã??ç??å????å¿?ã??è¡?ã?ä¿?é?²å?¤?å??ã??æ??ã????è??ã?ã??ã??ã??ã??ã???ã???ã?ã?ã?? ã???ã?ã??ã?ªã??ã?½ã?¼ã? ?å¤???è??ç?½?ï¼?å®?é????é???è¤?é???ã?ªã???ã?¿ã?³ã??ã?¯?ï¼??æ§?æ?ã?ã???ã??ã?ã?ã??ã??ã???è??ç?½??ã?ªã??ã?½ã?¼ã? ??é??ç??æ§?é? ã???ã?ã??é?¨å??ã?ã??ã???ã?ã??

??ã??è??å?³?ã?ã???ã??é???ã?²ã??ã? é?å???æ??å?æ???ã?ã?ã??ã??ã??ã???ã?²ã??ã?  DNA?ã??ã??ä¸?é?¨å????ã?è??ç?½?ã??ã?³ã?¼ã??å??ã??ã?ã??ã??ã?å?¤æ??ã??ã?ã?ã?? ç§??è???å½?å?è??ã??ã?ã?ã?? "ã?ã??ã??ã?¸ã?£ã?³ã?¯DNA?ä½?è?????ã?ã?ã?ï¼?"ã?"ã??ã?¸ã?£ã?³ã?¯DNAã??å?ã??é?¤ã?ã?ã???ã??ã????ã?ã?ã?ï¼?"?ã?? ä»?æ?¥??ã??é????è??å????æ§?ã????ç¯?ç???å?????ã???ã?ï¼?ã??ã?¸ã?£ã?³ã?¯ DNA ?é?¨å???ç?±?ã?ã??ï¼??ã??RNAã?ã?ã?ã??ã?? miRNAï¼?ã??ã?¤ã?¯ã?­RNAï¼??ã??ã??æ?¯é?ã?ã???ã?ã???ã?ã?ã??ã?æ??ã??ã??????ã???ã?ã?? ?ã???ä½??æ§?ã????é¡??å?¨???è?????ã??ã????ç?©?ï¼?DNAï¼??å?ºæ?¬ç???å?ä¸??ã?ã??ã????ã??è??ã?ç­?è??ã??è?è???ã??æ??æ¯??è?????å??å??ã?ã??é??ã?ä¾?ã??ç?®è???è????ã?????è??ã?ç?®è???è????ã????å®??ã?ã???å?²ã??ã?? miRNA ã?æ??ã?ã??ã?ã??ã??ã????ã?ã?? ã?ã???ã?å¤???ç????ã?å??ã?ã??ã??è??å???å?¶??å?¹ã?? miRNA ã??ã?­ã??ã?¡ã?¤ã?« ã????ã?ã??ã??ã??ã??ã?³ã?³ã??ã?­ã?¼ã?«æ©?è?½ã????ã? miRNA ã?ç???ç?ºç???å? ?ã?ã?è??ã?ã??ã???ã??ã?ã?? ?ã?ã?ã?¦ã?¤ã?«ã?¹ã?æ¨?ç???ã?ã???è???å?¶?ã??ä¹??å?ã??ï¼?ç??æ°???ã??ï¼?miRNAã??æ????ã??äº?ä¾?ã??ç?ºè¦?ã?ã???ã??ã?ã??

?ã?ã?ã?ã??ã?ã??ã???ã??ã?ã??RNA Worldã??ã?­ã?¸ã?§ã?¯ã??ã??é?ç?¨ã?ã??ã??ã?? RNAç ???æ??è³?ã??ã???ã???ã?ã?ã???ã??é???ç?ºè¦?ã??å¾?ã??ã??ã???å?±?ã?å°????ã????????ã??é????é?¿ã??ä¸?ã?ã??ã?????ã?ã??ã????ã??ã???æ?­è¨???ã????ã?ã??

å?è??æ??ç?®

(1) Infernal 1.0: inference of RNA alignments. Nawrocki EP, Kolbe DL, Eddy SR. Bioinformatics. 2009 May 15;25(10):1335-7. Epub 2009 Mar 23. PMID: 19307242.

(2) Rfam: updates to the RNA families database. Gardner PP, Daub J, Tate JG, Nawrocki EP, Kolbe DL, Lindgreen S, Wilkinson AC, Finn RD, Griffiths-Jones S, Eddy SR, Bateman A. Nucleic Acids Res. 2009 Jan;37(Database issue):D136-40. Epub 2008 Oct 25. PMID: 18953034.

(3) Petabyte-scale innovations at the European Nucleotide Archive. Cochrane G, Akhtar R, Bonfield J, Bower L, Demiralp F, Faruque N, Gibson R, Hoad G, Hubbard T, Hunter C, Jang M, Juhos S, Leinonen R, Leonard S, Lin Q, Lopez R, Lorenc D, McWilliam H, Mukherjee G, Plaister S, Radhakrishnan R, Robinson S, Sobhany S, Hoopen PT, Vaughan R, Zalunin V, Birney E. Nucleic Acids Res. 2009 Jan;37(Database issue):D19-25. Epub 2008 Oct 31. PMID: 18978013.